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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 9 Reviews
8.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
ALDH2 mutation and CoQ10 impacts
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.
Moderate relevance due to context
Our investigation centered around the effects of a genetic mutation in the ALDH2 enzyme, known as ALDH2*2, on the risk of developing atrial fibrillation (AF). We discovered that this mutation led to an increased incidence of AF in mice, accompanied by a decrease in the threshold for AF events compared to their non-mutant counterparts.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
Read More
7
CoQ10 may reduce AF incidence
Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure.
Mixed effects noted for CoQ10
We explored the potential benefits of coenzyme Q10 (CoQ10) in reducing the incidence of atrial fibrillation (AF) among patients with heart failure (HF). To do this, we conducted a study where patients were randomized into two groups: one received standard heart failure medications along with CoQ10, while the other group received only the standard treatment.
Throughout the study, we closely monitored the patients' heart rhythms and measured levels of inflammatory markers over a period of 12 months. Our findings revealed some intriguing results. We observed a significant decrease in malondialdehyde levels—a marker of oxidative stress—in the CoQ10 group. Notably, episodes of atrial fibrillation were seen in only 3 patients (6.3%) taking CoQ10, compared to 12 patients (22.2%) in the control group after a year of treatment. This difference was statistically significant.
These results suggest that coenzyme Q10 may indeed help reduce the occurrence of atrial fibrillation in heart failure patients, potentially related to its antioxidant properties. However, it’s important to note that while CoQ10 shows promise, more research is needed to fully understand its effects when used alongside existing medications.
Throughout the study, we closely monitored the patients' heart rhythms and measured levels of inflammatory markers over a period of 12 months. Our findings revealed some intriguing results. We observed a significant decrease in malondialdehyde levels—a marker of oxidative stress—in the CoQ10 group. Notably, episodes of atrial fibrillation were seen in only 3 patients (6.3%) taking CoQ10, compared to 12 patients (22.2%) in the control group after a year of treatment. This difference was statistically significant.
These results suggest that coenzyme Q10 may indeed help reduce the occurrence of atrial fibrillation in heart failure patients, potentially related to its antioxidant properties. However, it’s important to note that while CoQ10 shows promise, more research is needed to fully understand its effects when used alongside existing medications.
Read More
7
Coenzyme Q10's variable effectiveness
Targeting oxidative stress in surgery: effects of ageing and therapy.
Acknowledges combined treatment effects
We explored the effects of coenzyme Q10 on atrial fibrillation in cardiac surgery patients. In a randomized trial focused on elective surgery cases, we observed that coenzyme Q10 treatment contributed to improved overall health outcomes.
Notably, our study also involved a combined regimen that included omega-3 fatty acids, alpha-lipoic acid, selenium, and magnesium orotate. While coenzyme Q10 appeared to play a role in reducing factors related to myocardial damage and atrial fibrillation, it's essential to recognize that these positive effects may be influenced by the other treatments used alongside it.
Therefore, although there was a noted improvement in the rates of atrial fibrillation, we must be cautious in attributing these outcomes solely to coenzyme Q10, as it was part of a broader, multifaceted treatment approach.
Notably, our study also involved a combined regimen that included omega-3 fatty acids, alpha-lipoic acid, selenium, and magnesium orotate. While coenzyme Q10 appeared to play a role in reducing factors related to myocardial damage and atrial fibrillation, it's essential to recognize that these positive effects may be influenced by the other treatments used alongside it.
Therefore, although there was a noted improvement in the rates of atrial fibrillation, we must be cautious in attributing these outcomes solely to coenzyme Q10, as it was part of a broader, multifaceted treatment approach.
Read More
Most Useful Reviews
9.5
Significant improvement
My mother suffered from atrial fibrillation for years, enduring frequent hospital visits. After a heart attack, she began taking coenzyme Q10, initially at 60-90 mg daily. Within five months, her arrhythmia attacks ceased, and her overall health improved. Now she takes 100 mg daily without interruption, having bought the supplement abroad at a much lower price. Both my husband and I have also started taking it, and we've noticed increased energy and better health.
Read More
10
Positive effects
After using this supplement, I noticed my atrial fibrillation symptoms have disappeared, and I feel much better overall.
Read More
9.5
Good for heart
As someone suffering from atrial fibrillation and cardiovascular disease, I value CoQ10 Bio from Doctor's Best. It's an excellent antioxidant, beneficial for both the brain and heart health, especially when taking statins. The capsules are easy to swallow and taste pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
9
ALDH2 mutation and CoQ10 impacts
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.
Moderate relevance due to context
Our investigation centered around the effects of a genetic mutation in the ALDH2 enzyme, known as ALDH2*2, on the risk of developing atrial fibrillation (AF). We discovered that this mutation led to an increased incidence of AF in mice, accompanied by a decrease in the threshold for AF events compared to their non-mutant counterparts.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
Read More
7
CoQ10 may reduce AF incidence
Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure.
Mixed effects noted for CoQ10
We explored the potential benefits of coenzyme Q10 (CoQ10) in reducing the incidence of atrial fibrillation (AF) among patients with heart failure (HF). To do this, we conducted a study where patients were randomized into two groups: one received standard heart failure medications along with CoQ10, while the other group received only the standard treatment.
Throughout the study, we closely monitored the patients' heart rhythms and measured levels of inflammatory markers over a period of 12 months. Our findings revealed some intriguing results. We observed a significant decrease in malondialdehyde levels—a marker of oxidative stress—in the CoQ10 group. Notably, episodes of atrial fibrillation were seen in only 3 patients (6.3%) taking CoQ10, compared to 12 patients (22.2%) in the control group after a year of treatment. This difference was statistically significant.
These results suggest that coenzyme Q10 may indeed help reduce the occurrence of atrial fibrillation in heart failure patients, potentially related to its antioxidant properties. However, it’s important to note that while CoQ10 shows promise, more research is needed to fully understand its effects when used alongside existing medications.
Throughout the study, we closely monitored the patients' heart rhythms and measured levels of inflammatory markers over a period of 12 months. Our findings revealed some intriguing results. We observed a significant decrease in malondialdehyde levels—a marker of oxidative stress—in the CoQ10 group. Notably, episodes of atrial fibrillation were seen in only 3 patients (6.3%) taking CoQ10, compared to 12 patients (22.2%) in the control group after a year of treatment. This difference was statistically significant.
These results suggest that coenzyme Q10 may indeed help reduce the occurrence of atrial fibrillation in heart failure patients, potentially related to its antioxidant properties. However, it’s important to note that while CoQ10 shows promise, more research is needed to fully understand its effects when used alongside existing medications.
Read More
7
Coenzyme Q10's variable effectiveness
Targeting oxidative stress in surgery: effects of ageing and therapy.
Acknowledges combined treatment effects
We explored the effects of coenzyme Q10 on atrial fibrillation in cardiac surgery patients. In a randomized trial focused on elective surgery cases, we observed that coenzyme Q10 treatment contributed to improved overall health outcomes.
Notably, our study also involved a combined regimen that included omega-3 fatty acids, alpha-lipoic acid, selenium, and magnesium orotate. While coenzyme Q10 appeared to play a role in reducing factors related to myocardial damage and atrial fibrillation, it's essential to recognize that these positive effects may be influenced by the other treatments used alongside it.
Therefore, although there was a noted improvement in the rates of atrial fibrillation, we must be cautious in attributing these outcomes solely to coenzyme Q10, as it was part of a broader, multifaceted treatment approach.
Notably, our study also involved a combined regimen that included omega-3 fatty acids, alpha-lipoic acid, selenium, and magnesium orotate. While coenzyme Q10 appeared to play a role in reducing factors related to myocardial damage and atrial fibrillation, it's essential to recognize that these positive effects may be influenced by the other treatments used alongside it.
Therefore, although there was a noted improvement in the rates of atrial fibrillation, we must be cautious in attributing these outcomes solely to coenzyme Q10, as it was part of a broader, multifaceted treatment approach.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.9
10
Positive effects
After using this supplement, I noticed my atrial fibrillation symptoms have disappeared, and I feel much better overall.
9.5
Significant improvement
My mother suffered from atrial fibrillation for years, enduring frequent hospital visits. After a heart attack, she began taking coenzyme Q10, initially at 60-90 mg daily. Within five months, her arrhythmia attacks ceased, and her overall health improved. Now she takes 100 mg daily without interruption, having bought the supplement abroad at a much lower price. Both my husband and I have also started taking it, and we've noticed increased energy and better health.
Read More
9.5
Effective aid
I bought Doctor's Best Coenzyme Q10 with Bioperine for my mother, who has atrial fibrillation after an early stroke. She feels much better since starting this supplement, which I now intend to purchase regularly.
9.5
Good for heart
As someone suffering from atrial fibrillation and cardiovascular disease, I value CoQ10 Bio from Doctor's Best. It's an excellent antioxidant, beneficial for both the brain and heart health, especially when taking statins. The capsules are easy to swallow and taste pleasant.
9.5
Heart improvement
This nutritional supplement supports heart health and has helped with my atrial fibrillation symptoms significantly.
